Increases in Sex Hormones during Anti-Tumor Necrosis Factor α Therapy in Adolescents with Crohn's Disease.

摘要: Objective To evaluate children with Crohn's disease for inverse relationships between systemic inflammatory cytokines and sex hormone regulation in the context of anti-tumor necrosis factor α (TNF-α) therapy. Study design An observational study was used to assess gonadotropin levels at time initiation anti-TNF-α therapy 10 weeks 12 months later 72 adolescents (Tanner stage 2-5) disease. Mixed-model linear regression levels, inflammation, dual-energy x-ray absorptiometry whole-body fat mass Z scores over interval. Results Sex increased significantly during 10-week induction interval: testosterone male patients from a median −0.36 0.40 ( P Conclusions is associated delayed maturation, significant rapid increases association improvements activity measures inflammation. These data are consistent preclinical studies effects inflammation on regulation.