3He MRI-based assessment of posture-dependent regional ventilation gradients in rats
作者： Sven Månsson , Anselm J. Deninger , Peter Magnusson , Göran Pettersson , Lars E. Olsson
DOI: 10.1152/JAPPLPHYSIOL.00245.2004
关键词:
摘要: A recently developed method for quantitative assessment of regional lung ventilation was employed the study posture-dependent differences in rats. The measurement hyperpolarized (3)He MRI to detect build-up signal intensity after increasing numbers breaths, which allowed computation a parameter. group six anesthetized rats studied both supine and prone postures. Three-dimensional maps parameter were obtained with high spatial resolution (voxel volume approximately 2 mm(3)). Vertical (dorsal-ventral) gradients index, defined as normalized by average within whole lung, investigated. Variations distribution parameter, well could be detected, depending on posture In posture, elevated dependent parts lungs, linear gradient index -0.11 +/- 0.03 cm(-1). more uniform, significantly (P < 0.001) smaller -0.01 0.02 It is concluded that MRI-based can quantify animals small rat these depend or animal.
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