Catalytic Asymmetric Synthesis of Allylsilanes through Rhodium/Chiral Diene-Catalyzed 1,4-Addition of Alkenyl[2-(hydroxymethyl)phenyl]dimethylsilanes
作者： Ryo Shintani , Yoshitaka Ichikawa , Tamio Hayashi , Jinshui Chen , Yoshiaki Nakao
DOI: 10.1021/OL702125Q
关键词:
摘要: A new synthetic method of chiral allylsilanes has been developed through a rhodium-catalyzed asymmetric 1,4-addition alkenyl[2-(hydroxymethyl)phenyl]dimethylsilanes to β-silyl α,β-unsaturated ketones. By employing (S,S)-Ph-bod* as ligand, range alkenyl nucleophiles have installed these substrates in high yield and enantiomeric excess. The resulting can be used for stereoselective intramolecular allylation reactions control two contiguous tertiary quaternary stereocenters.
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