Association of IgG anti-GD1a antibody with severe Guillain-Barré syndrome.
作者： Nobuhiro Yuki , Mitsunori Yamada , Shuzo Sato , Eisaku Ohama , Yasuhiro Kawase
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摘要: We earlier reported cases of 2 patients with severe acute Guillain–Barre syndrome (GBS) associated high-IgG anti-GD1a antibody titer. now have investigated the autoantibody against GD1a or GM1 in 37 GBS using enzyme-linked immunosorbent assay and found a statistically significant association between IgG severity disease (need respiratory for more than 1 month poor functional prognosis 3 months after neurologic onset). An autopsy which showed produced following findings: (1) axonal degeneration segmental demyelination peripheral nerves; (2) lymphocytic infiltration; (3) marked central chromatolysis lower motoneurons. © 1993 John Wiley & Sons, Inc.
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