Salicylate-induced morphological changes of isolated inner hair cells and outer hair cells from guinea-pig cochlea

摘要: Abstract Objectives The aim of this study is to investigate the salicylate-induced morphological changes cochlear inner hair cells (IHCs) and outer (OHCs). Methods IHCs OHCs were acutely isolated from guinea-pig cochlea. Cells observed under inverted microscope 10 mmol/L sodium salicylate solutions or 0.01 mmol/L dexamethasone-plus-salicylate applied. cell length ratio between width was indices in cells. Results Isolated did not demonstrate any significant 20 min 40 min, whereas shortened by 83% 75% 40 min. There no differences control after 40 min both OHCs. Conclusions Although affected cochlea, changed morphologically applications. Dexamethasone inhibited