Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

摘要: Toxoplasma gondii (T. gondii) is a neurotropic parasite that associated with various neuropsychiatric disorders. Rodents infected T. display plethora of behavioural alterations, and infection in humans has been strongly disorders such as schizophrenia, which impaired social behaviour an important feature. Elucidating changes at the cellular level relevant to conditions can lead effective therapies. Here, we compare during acute chronic female mice. Further, notice phase infection, mice sociability when exposed novel conspecific. Also, show short-term recognition memory. However, object memory remains intact. Using c-Fos marker neuronal activity, leads impairment activation medial prefrontal cortex, hippocampus well amygdala are environment change functional connectivity between these regions. We found synaptic proteins play role process synaptophysin, PSD-95 downstream substrates cell activity cyclic AMP, phospho-CREB BDNF. Our results point towards imbalance wider range problems upon infection.