INTERFERON-GAMMA -INDUCIBLE REGULATION OF THE HUMAN INVARIANT CHAIN GENE
作者： C L Barr , G F Saunders
DOI: 10.1016/S0021-9258(19)67820-8
关键词:
摘要: Interferon-gamma (IFN-gamma) regulates a variety of immunoregulatory functions through the induction specific set IFN-gamma response genes. This includes invariant chain associated with major histocompatibility complex class II molecules. To investigate mechanism involved in (In) to we constructed chloramphenicol acetyltransferase (CAT) hybrid genes which CAT gene is under control In promoter. The glioblastoma cell line, U-373 MG, transfected construct having promoter sequence -790 +1 bp showed over 3-fold increased activity when treated indicating that this region confers responsiveness gene. element was further sublocalized -120 -61 base pairs (bp). contains homology interferon-stimulated elements identified other IFN responsive By gel shift analyses, an IFN-gamma-induced sequence-specific DNA-binding factor identified. induced binds oligonucleotide corresponding -107 -79 Mutations binding site at -94 and -92 drastically decreased constitutive complexes. also -91 -62 interferon-beta (IFN-beta) promoter, necessary for IFN-beta by virus double-stranded RNA. specificity characteristic family DNA factors bind both
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