Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.

摘要: The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety ligands bind specifically to them and these receptors control gene networks that have profound effects on growth, development, homeostasis. ligand-receptor complexes recognize transcriptional enhancer DNA sequences, the response elements, resulting in induction or repression activity. similarity between all as well themselves, indicates conserved general strategy for hormonal transcription steroids. activated responsive promoters most likely mediate assembly stage- tissue-specific factor stimulate inhibit expression.