Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs.
作者： R.K. Jackson , L.P. Liew , M.P. Hay
DOI: 10.1016/J.CLON.2019.02.004
关键词:
摘要: … Tumour hypoxia is a well-validated target for oncology drug development, particularly in … hypoxic tumour cells and explore recent efforts to develop hypoxic cell sensitisers and hypoxia-…
sci-hub.se 
researchgate.net 参考文章(220)
Michael P. Hay, Kevin O. Hicks, Jingli Wang, Hypoxia-Directed Drug Strategies to Target the Tumor Microenvironment Advances in Experimental Medicine and Biology. ,vol. 772, pp. 111- 145 ,(2014) , 10.1007/978-1-4614-5915-6_6
W. A. Denny, W. R. Wilson, M. P. Hay, Recent developments in the design of bioreductive drugs. The British journal of cancer. Supplement. ,vol. 27, ,(1996)
S Dische, M Saunders, Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide. The British journal of cancer. Supplement. ,vol. 27, ,(1996)
Alan C. Sartorelli, Sara Rockwell, Katherine A. Kennedy, Preferential Activation of Mitomycin C to Cytotoxic Metabolites by Hypoxic Tumor Cells Cancer Research. ,vol. 40, pp. 2356- 2360 ,(1980)
Lan Yu, Zeng-Fu Shang, Feng-Ming Hsu, Zhang Zhang, Vasu Tumati, Yu-Fen Lin, Benjamin P.C. Chen, Debabrata Saha, NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor Oncotarget. ,vol. 6, pp. 3848- 3860 ,(2015) , 10.18632/ONCOTARGET.2975
Roger M Phillips, Hans R Hendriks, Godefridus J Peters, , EO9 (Apaziquone): from the clinic to the laboratory and back again British Journal of Pharmacology. ,vol. 168, pp. 11- 18 ,(2013) , 10.1111/J.1476-5381.2012.01996.X
C. von Sonntag, The chemical basis of radiation biology ,(1987)
Maria R Abbattista, Stephen M F Jamieson, Yongchuan Gu, Jennifer E Nickel, Susan M Pullen, Adam V Patterson, William R Wilson, Christopher P Guise, Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma. Cancer Biology & Therapy. ,vol. 16, pp. 610- 622 ,(2015) , 10.1080/15384047.2015.1017171
Kevin O Hicks, Frederik B Pruijn, Joanna R Sturman, William A Denny, William R Wilson, None, Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures. Cancer Research. ,vol. 63, pp. 5970- 5977 ,(2003)
C J Koch, Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Research. ,vol. 53, pp. 3992- 3997 ,(1993)