作者: Lesley-Anne Furlong
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摘要: OBJECTIVE: To alert clinicians to the risk of ectopic pregnancy when certain contraceptive methods fail by summarizing data from trials reviewed U.S. Food and Drug Administration (FDA). STUDY DESIGN: The review focuses on 7 drug products with an increased method fails. Data were extracted reviews clinical submitted FDA support marketing applications medical literature. 6 other published for tubal ligations are used comparisons. This does not include medroxyprogesterone acetate injections because this did any outcome information. RESULTS: results presented in a table compared postmarketing surveillance reports literature available. proportion pregnancies among all ranged 1:2 1:21 intrauterine devices progestin-only implants oral contraceptives. Although confidence intervals proportions large few both calculated trial data. CONCLUSION: Pregnancies women using contraceptives more likely be than general population. (authors)