Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.

摘要: Treating Alzheimer’s disease and related dementias is one of the major challenges currently facing healthcare providers worldwide. A hallmark formation large deposits a specific molecule, known as amyloid beta (Aβ), in brain. However, more research suggests that smaller particularly toxic clumps – often referred to oligomeric Aβ appear an early sign disease. To understand how these triggers other aspects disease, it important identify molecules human brain binds to. this end, Wang et al. attached or microscopically small beads. The beads were then exposed extracts test tube, which allowed bind Aβ. samples spun at high speed, meaning any bound them sunk formed pellets bottom tubes. Each pellet was analyzed see contained. experiments identified than hundred proteins can beta. One them, somatostatin, selectively able determine structural features somatostatin control binding. Finally, further performed tubes, noticed likely form larger when present. This could signify previously unrecognized role development Further studies are now needed confirm whether presence favors smaller, over innocuous deposits. If so, new treatments be developed aim reduce levels by preventing from interacting with molecules. also suggest used diagnostic tests detect abnormal body fluids people who have