Vagus nerve stimulation modulates complexity of heart rate variability differently during sleep and wakefulness

摘要: Progressive loss of heart rate variability (HRV) and complexity are associated with increased risk mortality in patients cardiovascular disease a candidate marker for at sudden cardiac death. HRV is influenced by the autonomic nervous system (ANS), although it unclear which arm ANS (sympathetic or parasympathetic) needs to be perturbed increase HRV. In this case-control study, we have analyzed relation between modulation vagus nerve stimulation (VNS) changes as function states vigilance. We hypothesize that VNS - being preferential activator parasympathetic will decrease (HR) maximum during sleep. The electrocardiogram (EKG) obtained from 37-year-old, right-handed male known intractable partial epilepsy left therapeutic was wakefulness sleep ON OFF states. Age-matched control EKG five participants (three two without epilepsy) had no implant. study demonstrated following: (1) decreased wakefulness. (2) An tone even presence HR. These results need replicated larger cohort before developing patterned using stabilize dysautonomia prevent fatal arrhythmias.