Lymphocyte blast transformation responses and viral antibodies in relation to HLA antigens in multiple sclerosis

摘要: Fifty four clinically stable multiple sclerosis (MS) patients and 54 age- sex-matched control subjects were HLA-typed, their responses to herpes simplex, measles, mumps rubella antigens examined by the lymphocyte blast transformation test serum antibody titrations. Blast response purified tuberculin (PPD), mitogen phytohaemagglutinin (PHA), pokeweed (PWN) concanavalin A (Con A) spontaneous proliferation of lymphocytes also studied. MS differed from controls higher levels measles viruses lower specific antigens. When relative strength was measured, simplex in than controls. In addition, 6-day cultures that lymphocytes. stimulations there no differences between whole groups, but oldest had PHA Con matched The frequency HLA-Dw2 56.6% 32.1% with without Dw2 each other only a PPD Dw2-positive group. immunological resembled patients: low viral antigens, elevated antibodies. This finding supports function genetically determined type immune responsiveness cell-mediated immunity high certain antibodies as one susceptibility factor sclerosis.