Investigation of particle packing in model pharmaceutical powders using X-ray microtomography and discrete element method
作者： Xiaowei Fu , Meenakshi Dutt , A. Craig Bentham , Bruno C. Hancock , Ruth E. Cameron
DOI: 10.1016/J.POWTEC.2006.06.011
关键词:
摘要: This paper outlines a novel technique, based on combination of modern desktop X-ray microtomography, quantitative image processing and computer simulation using the discrete element method (DEM), to investigate randomly packed particles in an attempt to model the process of pharmaceutical tablet manufacture by powder compaction. The systems studied include glass ballotini and spheroidal micronised cellulose (Celphere), all with typical particle sizes between 180 and 300 μm. We demonstrate that X-ray microtomography (XMT) …
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