Tympanosclerosis in the rat tympanic membrane: an experimental study.

摘要: Objectives/Hypothesis Tympanosclerosis is a pathologic condition affecting the middle ear and tympanic membrane. It common in humans, most notably after grommet insertion. However, pathogenesis of this disease unclear. The aim study was to investigate development progression tympanosclerosis pars tensa rat membranes at various time intervals inducing sterile effusions. Methods Fifty-six male-specific, pathogen-free CD Wistar rats (100–170 g) underwent unilateral eustachian tube obstruction. Contralateral ears served as controls. Only specimens from animals with effusions were included study. Light electron microscopic analysis performed on induced ranging 1 12 months. Results Histologic changes consistent seen majority 3 months greater. process started submucosal connective tissue layer progressed involve all sublayers. extent calcium deposition fibrosis across membrane related duration otitis media effusion. Atrophy not found any specimens. Conclusions progressive disorder, which appears be main response prolonged involvement different sublayers closely We propose that new model for effusion therefore suitable animal tensa.