Electron microscopic observations on the repair of perforated tympanic membranes in the guinea-pig.

摘要: Experimental perforations of the tympanic membrane in guinea-pig have been examined electron microscopically. The perforation site became filled with maturing granulation tissue, covered on its external (meatal) and internal (middle ear) surfaces by cells derived from epithelia respective normal membrane. fibrils interfibrillar matrix this species a unique ultrastructure. are quadrangular, apparently composed four subunits, surrounding is more electron-dense than most connective tissues. During repair type fibril was not reconstituted within 6 month period examined. In place were formed varying diameter, probably collagenous, differing those both size lack characteristic matrix. fibroblasts wound site, even if local origin, thus do appear to be capable synthesizing tissue.