Opioid Use After Total Knee Arthroplasty: Does Tramadol Have Lower Risk Than Traditional Opioids?

摘要: Abstract Background Preoperative opioid use has been shown to increase postoperative following total knee arthroplasty (TKA). Tramadol is recommended for symptomatic treatment of osteoarthritis; however, it acts on receptors and may confer similar adverse effects. The purpose this study assess with preoperative tramadol use. Methods Patients undergoing primary TKA were identified in the Humana administrative claims database. stratified by whether they filled a prescription an opioid, tramadol, either, or neither within 3 months TKA. Prescription tracked 12 postoperatively relative risk each group was calculated. Results In total, 107,973 patients identified. Preoperatively, 29,890 (27.7%) opioids, 8049 (7.5%) 44,403 (41.1%) 63,570 (58.9%) did not fill either. At postoperatively, 6.0% narcotic-free patients, 35.2% users (relative [RR] 5.83 [5.63-6.03]), 9.2% (RR 1.52 [1.40-1.63]), 29.5% 4.88 [4.72-5.05]). Opioid prescriptions 7.7% 37.3% 4.84 [4.70-4.99]), 26.2% 3.40 [3.26-3.57]), 35.7% 4.64 [4.50-4.78]) at months. Conclusion taking preoperatively found be lower prolonged either narcotics continued these medications higher rate than those who not.