Hopping between Differentiation States in Lung Adenocarcinoma

Akihiko Yoshizawa, Noriko Motoi, Gregory J Riely, Cami S Sima, William L Gerald, Mark G Kris, Bernard J Park, Valerie W Rusch, William D Travis, Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases Modern Pathology. ,vol. 24, pp. 653- 664 ,(2011) , 10.1038/MODPATHOL.2010.232

Eric L. Snyder, Hideo Watanabe, Margaret Magendantz, Sebastian Hoersch, Tiffany A. Chen, Diana G. Wang, Denise Crowley, Charles A. Whittaker, Matthew Meyerson, Shioko Kimura, Tyler Jacks, Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma Molecular Cell. ,vol. 50, pp. 185- 199 ,(2013) , 10.1016/J.MOLCEL.2013.02.018

Eugenia C. Pacheco-Pinedo, Amy C. Durham, Kathleen M. Stewart, Ashley M. Goss, Min Min Lu, Francesco J. DeMayo, Edward E. Morrisey, Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium Journal of Clinical Investigation. ,vol. 121, pp. 1935- 1945 ,(2011) , 10.1172/JCI44871

Yutaka Maeda, Tomoshi Tsuchiya, Haiping Hao, David H. Tompkins, Yan Xu, Michael L. Mucenski, Lingling Du, Angela R. Keiser, Takuya Fukazawa, Yoshio Naomoto, Takeshi Nagayasu, Jeffrey A. Whitsett, Kras G12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung Journal of Clinical Investigation. ,vol. 122, pp. 4388- 4400 ,(2012) , 10.1172/JCI64048

L. Lin, A. J. Bass, W. W. Lockwood, Z. Wang, A. L. Silvers, D. G. Thomas, A. C. Chang, J. Lin, M. B. Orringer, W. Li, T. W. Glover, T. J. Giordano, W. L. Lam, M. Meyerson, D. G. Beer, Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 4251- 4256 ,(2012) , 10.1073/PNAS.1011989109

Zhan Yin, Linda Gonzales, Venkatadri Kolla, Nibedita Rath, Yuzhen Zhang, Min Min Lu, Shioko Kimura, Philip L. Ballard, Michael F. Beers, Jonathan A. Epstein, Edward E. Morrisey, Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 291, ,(2006) , 10.1152/AJPLUNG.00385.2005

Yuzhen Zhang, Ashley M Goss, Ethan David Cohen, Rachel Kadzik, John J Lepore, Karthika Muthukumaraswamy, Jifu Yang, Francesco J DeMayo, Jeffrey A Whitsett, Michael S Parmacek, Edward E Morrisey, A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration Nature Genetics. ,vol. 40, pp. 862- 870 ,(2008) , 10.1038/NG.157

Julian Carretero, Takeshi Shimamura, Klarisa Rikova, Autumn L. Jackson, Matthew D. Wilkerson, Christa L. Borgman, Matthew S. Buttarazzi, Benjamin A. Sanofsky, Kate L. McNamara, Kathleyn A. Brandstetter, Zandra E. Walton, Ting-Lei Gu, Jeffrey C. Silva, Katherine Crosby, Geoffrey I. Shapiro, Sauveur-Michel Maira, Hongbin Ji, Diego H. Castrillon, Carla F. Kim, Carlos García-Echeverría, Nabeel Bardeesy, Norman E. Sharpless, Neil D. Hayes, William Y. Kim, Jeffrey A. Engelman, Kwok-Kin Wong, Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors Cancer Cell. ,vol. 17, pp. 547- 559 ,(2010) , 10.1016/J.CCR.2010.04.026

William K.C. Cheung, Minghui Zhao, Zongzhi Liu, Laura E. Stevens, Paul D. Cao, Justin E. Fang, Thomas F. Westbrook, Don X. Nguyen, Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis Cancer Cell. ,vol. 23, pp. 725- 738 ,(2013) , 10.1016/J.CCR.2013.04.009

Monte M. Winslow, Talya L. Dayton, Roel G. W. Verhaak, Caroline Kim-Kiselak, Eric L. Snyder, David M. Feldser, Diana D. Hubbard, Michel J. DuPage, Charles A. Whittaker, Sebastian Hoersch, Stephanie Yoon, Denise Crowley, Roderick T. Bronson, Derek Y. Chiang, Matthew Meyerson, Tyler Jacks, Suppression of lung adenocarcinoma progression by Nkx2-1 Nature. ,vol. 473, pp. 101- 104 ,(2011) , 10.1038/NATURE09881