Kras G12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung
作者： Yutaka Maeda , Tomoshi Tsuchiya , Haiping Hao , David H. Tompkins , Yan Xu
DOI: 10.1172/JCI64048
关键词: Haploinsufficiency 、 NK2 homeobox 1 、 Transcription factor 、 Gene expression 、 Tumor progression 、 Cancer research 、 Carcinogenesis 、 Adenocarcinoma of the lung 、 Biology 、 KRAS
摘要: … , were readily detected in goblet cells in lung tumors of Kras G12D ;Nkx2-1 +/– mice and in airways of HDM-challenged mice, but were absent in tumors induced in Kras G12D ;Nkx2-1 +/…
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sci-hub.st 参考文章(58)
Hongkai Ji, Hui Jiang, Wenxiu Ma, David S Johnson, Richard M Myers, Wing H Wong, An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nature Biotechnology. ,vol. 26, pp. 1293- 1300 ,(2008) , 10.1038/NBT.1505
Alvin M. Malkinson, Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung Lung Cancer. ,vol. 32, pp. 265- 279 ,(2001) , 10.1016/S0169-5002(00)00232-4
Shingo Kato, Ryota Hokari, Suzanne Crawley, James Gum, Dae-Ho Ahn, Jong-Woo Kim, Sung-Won Kwon, Soichiro Miura, Carol B Basbaum, Young S Kim, None, MUC5AC mucin gene regulation in pancreatic cancer cells. International Journal of Oncology. ,vol. 29, pp. 33- 40 ,(2006) , 10.3892/IJO.29.1.33
Jacek Majewski, Jurg Ott, Distribution and Characterization of Regulatory Elements in the Human Genome Genome Research. ,vol. 12, pp. 1827- 1836 ,(2002) , 10.1101/GR.606402
Songcang Chen, Christopher L. Grigsby, Christopher S. Law, Xiping Ni, Nada Nekrep, Keith Olsen, Michael H. Humphreys, David G. Gardner, Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents Journal of Clinical Investigation. ,vol. 119, pp. 1647- 1658 ,(2009) , 10.1172/JCI35314
Gregor Fürstenberger, Hans-Jörg Senn, Insulin-like growth factors and cancer. Lancet Oncology. ,vol. 3, pp. 298- 302 ,(2002) , 10.1016/S1470-2045(02)00731-3
Jeffrey A Engelman, Liang Chen, Xiaohong Tan, Katherine Crosby, Alexander R Guimaraes, Rabi Upadhyay, Michel Maira, Kate McNamara, Samanthi A Perera, Youngchul Song, Lucian R Chirieac, Ramneet Kaur, Angela Lightbown, Jessica Simendinger, Timothy Li, Robert F Padera, Carlos García-Echeverría, Ralph Weissleder, Umar Mahmood, Lewis C Cantley, Kwok-Kin Wong, Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers Nature Medicine. ,vol. 14, pp. 1351- 1356 ,(2008) , 10.1038/NM.1890
Kazi Nazrul Islam, Carole R. Mendelson, Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms. Molecular and Cellular Biology. ,vol. 26, pp. 2901- 2912 ,(2006) , 10.1128/MCB.26.8.2901-2912.2006
Heike Laman, Juan M Funes, Hongtao Ye, Stephen Henderson, Laura Galinanes-Garcia, Eiji Hara, Phillip Knowles, Neil McDonald, Chris Boshoff, Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6 The EMBO Journal. ,vol. 24, pp. 3104- 3116 ,(2005) , 10.1038/SJ.EMBOJ.7600775
G. T. Stathopoulos, T. P. Sherrill, D.-S. Cheng, R. M. Scoggins, W. Han, V. V. Polosukhin, L. Connelly, F. E. Yull, B. Fingleton, T. S. Blackwell, Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 18514- 18519 ,(2007) , 10.1073/PNAS.0705316104