Dysregulation of the TSC-mTOR pathway in human disease.

作者: Ken Inoki , Michael N Corradetti , Kun-Liang Guan

DOI: 10.1038/NG1494

关键词:

摘要: … of amino acids in the cell and inhibits the TSC complex or activates the mTOR pathway somewhere between the TSC complex and mTOR complex. IRS, insulin receptor substrate. …

参考文章(98)
Y. Kamada, T. Sekito, Y. Ohsumi, Autophagy in Yeast: ATOR-Mediated Response to Nutrient Starvation Current Topics in Microbiology and Immunology. ,vol. 279, pp. 73- 84 ,(2004) , 10.1007/978-3-642-18930-2_5
T Tucker, JM Friedman, Pathogenesis of hereditary tumors: beyond the “two-hit” hypothesis Clinical Genetics. ,vol. 62, pp. 345- 357 ,(2002) , 10.1034/J.1399-0004.2002.620501.X
Nisreen El-Hashemite, David J. Kwiatkowski, Hongbing Zhang, Victoria Walker, Loss of Tsc1 or Tsc2 Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin Cancer Research. ,vol. 63, pp. 5173- 5177 ,(2003)
I Hernan, I Roig, B Martin, M J Gamundi, M Martinez-Gimeno, M Carballo, De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. Clinical Genetics. ,vol. 66, pp. 58- 62 ,(2004) , 10.1111/J.0009-9163.2004.00266.X
Charis Eng, PTEN: One Gene, Many Syndromes Human Mutation. ,vol. 22, pp. 183- 198 ,(2003) , 10.1002/HUMU.10257
Estela Jacinto, Michael N. Hall, Tor signalling in bugs, brain and brawn. Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 117- 126 ,(2003) , 10.1038/NRM1018
Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru, Duojia Pan, Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nature Cell Biology. ,vol. 4, pp. 699- 704 ,(2002) , 10.1038/NCB847
Xiao-Ping Zhou, Kelly Woodford-Richens, Rainer Lehtonen, Keisuke Kurose, Micheala Aldred, Heather Hampel, Virpi Launonen, Sanno Virta, Robert Pilarski, Reijo Salovaara, Walter F. Bodmer, Beth A. Conrad, Malcolm Dunlop, Shirley V. Hodgson, Takeo Iwama, Heikki Järvinen, Ilmo Kellokumpu, J.C. Kim, Barbara Leggett, David Markie, Jukka-Pekka Mecklin, Kay Neale, Robin Phillips, Juan Piris, Paul Rozen, Richard S. Houlston, Lauri A. Aaltonen, Ian P.M. Tomlinson, Charis Eng, Germline Mutations in BMPR1A/ALK3 Cause a Subset of Cases of Juvenile Polyposis Syndrome and of Cowden and Bannayan-Riley-Ruvalcaba Syndromes American Journal of Human Genetics. ,vol. 69, pp. 704- 711 ,(2001) , 10.1086/323703
Nabeel Bardeesy, Manisha Sinha, Aram F. Hezel, Sabina Signoretti, Nathaniel A. Hathaway, Norman E. Sharpless, Massimo Loda, Daniel R. Carrasco, Ronald A. DePinho, Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation Nature. ,vol. 419, pp. 162- 167 ,(2002) , 10.1038/NATURE01045