Clinical Efficacy of L-Ornithine–L-Aspartate in the Management of Hepatic Encephalopathy

摘要: The clinical efficacy of both oral and parenteral L-ornithine-L-aspartate (OA) was confirmed by randomized, placebo-controlled, double-blind studies in patients with manifest hepatic encephalopathy hyperammonemia. drug able to reduce high blood ammonia levels induced either ammonium chloride or protein ingestion existing as a complication cirrhosis per se. Furthermore, OA improved performance Number Connection Test-A well mental state gradation. In contrast the positive effects observed more advanced encephalopathy, does not seem affect minimal encephalopathy. recent trial, decreased breakdown stimulated synthesis muscle. therapy had little side effects, increasing higher intravenously administered dosages, tolerated after administration.