Radiotherapy Targeting Cancer Stem Cells: Current Views and Future Perspectives

摘要: Increasing evidence suggests that many types of cancers contain a population cells display stem cell properties. These are called cancer (CSCs). They virtually resistant to radiation, and may contribute treatment resistance recurrence. Therefore, therapies specifically targeting CSCs will likely be needed for complete tumor eradication. In this article, we review published reports identifying the mechanisms radioresistance CSCs, potential markers predict response radiotherapy when using treatment. According reports, main compared non-CSCs self-renewal capacity, DNA-repair capacity enhanced reactive oxygen species defenses. Many kinds have several cell-surface markers, such as cluster differentiation (CD)133 CD144, these appear prognostic factors outcomes. Concerning therapeutic targets indicated pathways self-renewal, CSC niche signal transduction CSCs. Other new therapies, carbon ion internal with copper- 64-diacetyl-bis (N4-methythiosemicarbazone) (64Cu-ATSM), promising treatments target Further elucidation regulate provide insights into identification other development novel innovative therapies.