Cerebral Blood Flow in a Healthy Circle of Willis and Two Intracranial Aneurysms: Computational Fluid Dynamics Versus Four-Dimensional Phase-Contrast Magnetic Resonance Imaging

摘要: Computational fluid dynamics (CFD) opens up multiple opportunities to investigate the hemodynamics of human vascular system. However, due numerous assumptions acceptance CFD among physicians is still limited in practice and validation through comparison mandatory. Time-dependent quantitative phase-contrast magnetic resonance imaging PC-MRI measurements a healthy volunteer two intracranial aneurysms were carried out at 3 7 Tesla. Based on acquired images, three-dimensional (3D) models reconstructed used for numerical simulations. Flow information from MR applied as boundary conditions. The four-dimensional (4D) velocity fields obtained by MRI qualitatively well quantitatively compared including cut planes vector analyses. For all cases high similarity patterns was observed. Additionally, analysis revealed good agreement between MRI. Deviations caused minor differences vessel actual lumen. comparisons diastole systole indicate that relative are intensified with increasing velocity. findings this study lead conclusion agree predicting velocities when realistic geometries conditions provided. Due considerably higher temporal spatial resolution MRI, complex flow can be further investigated order evaluate their role respect aneurysm formation or rupture. Nevertheless, special care required regarding reconstruction since geometry has major impact subsequent results.