Growth factor regulation of neurogenesis in adult olfactory epithelium.

摘要: Neurogenesis continues throughout adult life in the mammalian olfactory epithelium. This process is a dynamic state of proliferation, differentiation and cell death, probably regulated by autocrine paracrine signals such as peptide growth factors. Previous investigations have demonstrated roles for some factors neurogenesis vitro, but assay systems used make it difficult to be certain their effects (proliferation, differentiation, enhanced survival) or target cells. The present study investigated cultures purified epithelium comprising only basal cells supporting serum-free media. advantage this culture system that survival neurons can examined separately. Under these conditions, three exerted well-defined effects: (i) fibroblast factor-2 stimulated proliferation globose cells; (ii) transforming factor-beta2 induced differentiate into neurons; (iii) platelet-derived factor promoted differentiated neurons. We conclude factor-2, act sequentially on precursor immature during