Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in non-neoplastic gastric mucosa.
作者： Tomomitsu Tahara , Tomoyuki Shibata , Masakatsu Nakamura , Masaaki Okubo , Hiromi Yamashita
DOI: 10.1111/J.1523-5378.2011.00821.X
关键词:
摘要: BACKGROUND: Genetic factors, related to DNA repair or xenobiotic pathways might confer different degrees of susceptibility gastric carcinogenesis. CpG island hyper methylation (CIHM) is a major event in We evaluated the association between XRCC1, GSTP1, GSTT1 and GSTM1 polymorphisms with CIHM status non-neoplastic mucosa. METHODS: XRCC1 Arg399Gln, Arg194Trp, GSTP1 Ile104Val, GSTT1, null were genotyped 415 cancer free subjects, relation four candidate (p14, p16, DAP-kinase CDH1) loci, assessed by Methylation-Specific-Polymerase Chain Reaction (MSP). high was defined as two more islands methylated. RESULTS: Significant codon 399 Gln/Gln genotype reduced (adjusted OR = 0.30, 95%CI = 0.13-0.71, p = .0055) (OR = 0.42, 95%CI = 0.19-0.97, p = .04). Gin/Gln also presented lower number when compared both Arg/Gln, Arg/Arg + Arg/Gln genotypes (p = .02, .046, respectively) When subjects divided according age (>50 <50), an found increased 50 years older generations (OR = 1.63, 95%CI = 1.01-2.62, p = .045). CONCLUSION: associated especially DAP-kinase. may increase patients. have role CIHM-related
sci-hub.se 参考文章(40)
Gregory P. Mullen, Assen Marintchev, Mary A. Mullen, Mark W. Maciejewski, Borlan Pan, Michael R. Gryk, Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nature Structural & Molecular Biology. ,vol. 6, pp. 884- 893 ,(1999) , 10.1038/12347
Mitsuru Kaise, Takuji Yamasaki, Jin Yonezawa, Jun Miwa, Yasuhiko Ohta, Hisao Tajiri, CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. Helicobacter. ,vol. 13, pp. 35- 41 ,(2008) , 10.1111/J.1523-5378.2008.00572.X
S Pemble, K R Schroeder, S R Spencer, D J Meyer, E Hallier, H M Bolt, B Ketterer, J B Taylor, Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal. ,vol. 300, pp. 271- 276 ,(1994) , 10.1042/BJ3000271
Hongbing Shen, Yaochu Xu, Yun Qian, Rongbin Yu, Yu Qin, Ling Zhou, Xinru Wang, Margaret R. Spitz, Qingyi Wei, Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. International Journal of Cancer. ,vol. 88, pp. 601- 606 ,(2000) , 10.1002/1097-0215(20001115)88:4<601::AID-IJC13>3.0.CO;2-C
J.-P. Issa, CpG-island methylation in aging and cancer. Current Topics in Microbiology and Immunology. ,vol. 249, pp. 101- 118 ,(2000) , 10.1007/978-3-642-59696-4_7
Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Yoshihito Nakagawa, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Makoto Watanabe, Hiromi Yamashita, Ichiro Hirata, Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis European Journal of Gastroenterology & Hepatology. ,vol. 21, pp. 613- 619 ,(2009) , 10.1097/MEG.0B013E32830E28B2
Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Ichiro Hirata, Tomiyasu Arisawa, Chronic nonsteroidal anti‐inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa Cancer Science. ,vol. 100, pp. 1192- 1197 ,(2009) , 10.1111/J.1349-7006.2009.01175.X
Dorota Butkiewicz, Marek Rusin, Curtis C. Harris, Mieczyslaw Chorazy, Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population. Human Mutation. ,vol. 15, pp. 577- 578 ,(2000) , 10.1002/1098-1004(200006)15:6<577::AID-HUMU11>3.0.CO;2-W
Tomas Lindahl, Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair. Mutation Research-reviews in Mutation Research. ,vol. 462, pp. 129- 135 ,(2000) , 10.1016/S1383-5742(00)00024-7
Bo Chen, Lei Cao, Yong Zhou, Ping Yang, Hong-Wei Wan, Gui-Qing Jia, Liu Liu, Xiao-Ting Wu, Glutathione S-Transferase T1 (GSTT1) Gene Polymorphism and Gastric Cancer Susceptibility: A Meta-Analysis of Epidemiologic Studies Digestive Diseases and Sciences. ,vol. 55, pp. 1831- 1838 ,(2010) , 10.1007/S10620-009-1000-4