Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV-negative women.

摘要: The association between seropositivity to virus-like particles (VLP) of human papillomavirus (HPV) types 16, 18, 31, 35, or 45 and subsequent cervical HPV infection was examined in 829 women with HIV 413 risk-matched HIV-negative women. We found no statistically significant differences HPV-seropositive HPV-seronegative the risk a new homologous type, exception reduced infections 4.5 years beyond baseline serology measurement HIV-positive [hazard ratio, 0.21; 95% confidence interval (CI), 0.05-0.89]. Among women, not associated related viruses "other" groups. slightly increased group-related viruses, but were only for 16 group (hazard 1.6; CI, 1.1-2.3) 18-seropositive 31-seropositive 1.45; 1.0-2.0). lack protective immune effect from natural is most likely due low level antibody elicited by and/or potential reactivation HPV, especially