Placental-Derived Stem Cells: Potential Clinical Applications

摘要: Placental-derived stem cells are easily accessible and do not have many of the limitations embryonic their derivatives for use in clinical trials. Preclinical animal studies using amnion and, more recently, human epithelial (hAECs) provided evidence exciting potential applications. We characterized hAECs derived from term gestational tissues investigated application treatment adult perinatal lung injury. Studies by our group shown that display key features pluripotent cells. They form teratomas after transplantation into testes immunodeficient mice, they restricted expression major histocompatibility antigens vitro. also appear to suppress lymphocyte proliferation. Collectively, these findings indicate may elicit minimal immune recognition following an allogeneic recipient native form. Our observations on reparative effects models injury encouraged us investigate as a cellular therapy bronchopulmonary dysplasia respiratory distress syndrome preterm infants. In utero ventilation model fetal sheep, preliminary results administration reduces inflammation fibrosis, thus providing novel very infant. research multipotential amnion-derived well revolutionize approach therapies.