MiR-92b regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN

摘要: MicroRNAs (miRNAs) have emerged to play important roles in tumorigenesis and drug resistance of human cancer. Fewer studies were explored the miR-92b on lung cancer cell growth cisplatin (CDDP). In this paper, we utilized real-time PCR verify was significantly up-regulated non-small (NSCLC) tissues compared matched adjacent normal tissues. vitro assay demonstrated that knock-down inhabits sensitized A549/CDDP cells CDDP. Furthermore, found could directly target PTEN, a unique tumor suppressor gene, which downregulated These data indicate an oncogene by regulates growth, chemosensitivity phenotype, serve as novel potential maker for NSCLC therapy.