Dendritic cells, implications on function from studies of the afferent lymph veiled cell

摘要: Studies of afferent lymph veiled cells (ALVC) show that the full biological function dendritic in peripheral tissue is not explained by a simple model which immature at body surface take up antigen, migrate via ducts, mature and then effectively present antigens to T-cells draining node. Furthermore, it evident from various investigations surfaces are homogeneous population cells. They comprise mixture cell phenotypes defined staining with monoclonal antibodies, different sub-populations have distinct functions roles vivo. The molecular basis for differences between subsets only now being explored but some progress has been made understanding role co-stimulatory molecules. It should be possible exploit knowledge these aid future vaccination strategies domesticated animals thereby improving animal health reducing economic loss, and, as consequence, human health. By deliberately targeting functionally either precursor or vivo, become feasible achieve an appropriately biased immune response.