Effects of acute stress on the day of proestrus on sexual behavior and ovulation in female rats: participation of the angiotensinergic system.

作者: Márcio Vinícius Fagundes Donadio , Aline Kunrath , Kizzy Ludnila Corezola , Celso Rodrigues Franci , Janete A Anselmo-Franci

DOI: 10.1016/J.PHYSBEH.2007.05.005

关键词:

摘要: Physical or emotional stress can affect the female reproductive physiology and angiotensin II (Ang II) is a hormone that participates in response also control of hormones. The present study aimed at evaluating effects acute morning afternoon proestrus on sexual behavior ovulation participation Ang stress-induced effects. Female rats with regular estrous cycles were used. Several different protocols tested proestrus: restraint 10 min; 1 h ether stress, respectively. was evaluated by injecting receptor antagonists (losartan PD123319) 15 min before stress. lordosis quotient recorded number oocytes counted. Plasma levels luteinizing hormone, progesterone, prolactin corticosterone measured. All types induced reduction oocytes. Restraint (1 h) significant quotient. Peripheral central losartan, but not PD123319, injections partly reverted proestrus. Acute reduced progesterone surges later same day. In conclusion, day physiology. Moreover, angiotensinergic system, through AT(1) receptors,

参考文章(54)
A Jindra, R Kvetnanský, Stress-induced activation of inactive renin. Molecular weight aspects. Journal of Biological Chemistry. ,vol. 257, pp. 5997- 5999 ,(1982) , 10.1016/S0021-9258(20)65093-1
J. C. Wingfield, R. M. Sapolsky, Reproduction and resistance to stress: When and how Journal of Neuroendocrinology. ,vol. 15, pp. 711- 724 ,(2003) , 10.1046/J.1365-2826.2003.01033.X
George Paxinos, The Rat nervous system : Elsevier Academic Press,. ,(1985)
Daniela Jezova, Tomasz Ochedalski, Alexander Kiss, Greti Aguilera, Brain angiotensin II modulates sympathoadrenal and hypothalamic pituitary adrenocortical activation during stress. Journal of Neuroendocrinology. ,vol. 10, pp. 67- 72 ,(2008) , 10.1046/J.1365-2826.1998.00182.X
Olaf Jöhren, Gilberto L. Sanvitto, Giorgia Egidy, Juan M. Saavedra, Angiotensin II AT1A Receptor mRNA Expression Is Induced by Estrogen–Progesterone in Dopaminergic Neurons of the Female Rat Arcuate Nucleus The Journal of Neuroscience. ,vol. 17, pp. 8283- 8292 ,(1997) , 10.1523/JNEUROSCI.17-21-08283.1997
JUAN M. SAAVEDRA, Brain and Pituitary Angiotensin Endocrine Reviews. ,vol. 13, pp. 329- 380 ,(1992) , 10.1210/EDRV-13-2-329
M.K. Breigeiron, M. Morris, A.B. Lucion, G.L. Sanvitto, Effects of angiotensin II microinjected into medial amygdala on male sexual behavior in rats. Hormones and Behavior. ,vol. 41, pp. 267- 274 ,(2002) , 10.1006/HBEH.2002.1771
Ines Armando, Simona Volpi, Greti Aguilera, Juan M. Saavedra, Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress. Brain Research. ,vol. 1142, pp. 92- 99 ,(2007) , 10.1016/J.BRAINRES.2007.01.037