Newer H2-receptor antagonists: clinical pharmacokinetics and drug interaction potential

摘要: Since H2-receptor antagonists are widely and successfully used in the treatment of peptic ulcer, several alternatives to standard agents cimetidine ranitidine have been developed. Promising 'new' candidates might be famotidine nizatidine. For proper selection appropriate drug, its pharmacokinetic properties interaction potential should known. All 'old' blockers eliminated relatively rapidly (t 1/2 ranges from 1.5 4 hours), mainly by renal route (glomerular filtration tubular secretion). They exhibit a linear disposition their distribution is similar. Absorption most complete for nizatidine, whereas demonstrates lowest effective plasma concentrations. etintidine shares same imidazole ring structure as cimetidine, it can also impair oxidative drug metabolism liver. In this respect, non-interacting nizatidine (like ranitidine) offer definite advantage. Based on very similar profiles, these 2 regarded older drugs group, at least some economic benefits result competition they will provide.