Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis.

摘要: Posttraumatic epilepsy is a common complication of traumatic brain injury (TBI), occurring in up to 15-20% patients with severe trauma. Trauma accounts for approximately 5% chronic the community. Because it condition, and because relatively short latency period between onset seizures, posttraumatic represents good model test antiepileptogenic therapies. However, several well-conducted clinical trials have failed demonstrate efficacy anticonvulsants. can arise through number mechanisms, which often coexist within single patient. Penetrating produces cicatrix cortex associated risk 50%, whereas nonpenetrating head may produce focal contusions intracranial hemorrhages, 30%. Furthermore, closed diffuse concussive injury, shearing axons selective damage vulnerable regions, such as hippocampus. The clinical, neurophysiologic, imaging, neuropathologic features or epileptogenicity differ these alternate mechanisms. It likely that better understanding subtypes resulting from trauma will be required successfully identify