Establishment and Characterization of JHUCS-1 Cell line Derived from Carcinosarcoma of the Human Uterus

作者: Kyosuke YAMADA , Toshiaki TACHIBANA , Yasushi IIDA , Kazu UEDA , Akihiko MISAWA

DOI: 10.1111/J.1749-0774.2004.TB00030.X

关键词:

摘要: The cell line designed JHUCS-1 was established from a carcinosarcoma (malignant mixed mesodermal tumor) of the uterus that surgically removed 57-year-old Japanese woman. We carefully examined histopathology original tumor after and noted differentiation into neuroendocrine carcinoma within tumor's epithelial components. Immunohistochemical staining tumorous tissue had been heterotransplanted positive for Leu7. Additionally, secretary granules were observed in grafted cells as determined by electron microscopy. These results support existence line.

参考文章(10)
G. Ueda, M. Yamasaki, Neuroendocrine carcinoma of the uterus. Current topics in pathology. Ergebnisse der Pathologie. ,vol. 85, pp. 309- 335 ,(1992) , 10.1007/978-3-642-75941-3_10
Steven G. Silverberg, Claude Gompel, Pathology in gynecology and obstetrics ,(1977)
Kaori Udagawa, Etsuko Miyagi, Tsuneo Nakazawa, Fumiki Hirahara, Yoji Nagashima, Hiroshi Minaguchi, Itsuo Gorai, Takendo Yanagibashi, Atsuko Taki, Uterine carcinosarcoma is derived from a single stem cell: An in vitro study International Journal of Cancer. ,vol. 72, pp. 821- 827 ,(1997) , 10.1002/(SICI)1097-0215(19970904)72:5<821::AID-IJC19>3.0.CO;2-B
Hiroshi Tsujioka, F. Eguchi, M. Emoto, T. Hachisuga, T. Kawarabayashi, K. Shirakawa, Small-Cell Carcinoma of the Endometrium : An Immunohistochemical and Ultrastructural Analysis Journal of Obstetrics and Gynaecology Research. ,vol. 23, pp. 9- 16 ,(1997) , 10.1111/J.1447-0756.1997.TB00798.X
Makoto Emoto, Hiroshi Iwasaki, Masahiro Kikuchi, Koichi Shirakawa, Tissue Polypeptide Antigen Production in a Uterine Carcinosarcoma Cell Line in a Serum-Free Culture Gynecologic Oncology. ,vol. 60, pp. 443- 449 ,(1996) , 10.1006/GYNO.1996.0071
Steven G. Silverberg, Francis J. Major, John A. Blessing, Bernard Fetter, Frederic B. Askin, Shu-Yuan Liao, Alexander Miller, Carcinosarcoma (Malignant Mixed Mesodermal Tumor) of the Uterus: A Gynecologic Oncology Group Pathologic Study of 203 Cases International Journal of Gynecological Pathology. ,vol. 9, pp. 1- 19 ,(1990) , 10.1097/00004347-199001000-00001
Chieko Ishiwata, Hiroshi Ishikawa, Isamu Ishiwata, Takashi Nagayama, Histogenesis and Culture of Human Uterine Carcinosarcoma Cancer Research. ,vol. 41, pp. 1978- 1983 ,(1981)
Lester Thompson, Bernard Chang, Sanford H. Barsky, Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. The American Journal of Surgical Pathology. ,vol. 20, pp. 277- 285 ,(1996) , 10.1097/00000478-199603000-00003
Frank Vellios, Richard W. Stander, Carl P. Huber, Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. American Journal of Clinical Pathology. ,vol. 39, pp. 496- 505 ,(1963) , 10.1093/AJCP/39.5.496