Angiotensin type 2 receptor in hypertensive cardiovascular disease.

摘要: Purpose of review The renin angiotensin system plays a key role in the development hypertension-induced cardiovascular remodeling and damage. Angiotensin II (Ang II) exerts its effects by acting on two distinct subtypes receptor, type 1 receptor (AT1R) 2 (AT2R). Whereas AT1R mediates most recognized actions Ang II, it appears that AT2R opposes, part, mediated AT1R. As is expressed adult tissues smaller numbers than AT1R, cell signaling have been less well characterized those Recent findings Current knowledge suggests stimulation vasodilation, antigrowth, proapoptotic antiinflammatory effects. Hence, can modulate as progression atherosclerosis. A protective has also documented humans, mainly during chronic inhibition. Furthermore, new nonpeptide agonist developed, with potential future therapeutic applications hypertensive conditions. Summary This article reviews expression function pathogenesis functional structural alterations induced hypertension system.