l-Arginine is a Radioprotector for Hematopoietic Progenitor Cells
作者： Linda L Pearce , Xichen Zheng , Sandra Martinez-Bosch , Patrick P Kerr , Pornsri Khlangwiset
DOI: 10.1667/RR1281.1
关键词:
摘要: l-Arginine is shown to protect hematopoietic progenitor (32D cl 3) cells from death due exposure γ radiation (137Cs). Some of the other intermediates in urea cycle, namely ornithine and citrulline, plus itself, were not found have any significant impact on cell survival after irradiation. Intriguingly, supplementation irradiated with l-arginine results decreased production peroxynitrite, suggesting that suppression superoxide generation by nitric oxide synthase one or more microenvironments an important factor observed radioprotection. The absence radioprotective effect at 3% oxygen also confirms involvement oxygen-derived species. Knockdown experiments (NOS) siRNAs NOS knockout animals confirm radioprotection associated nNOS (NOS-1). ameliorates transient inhibition electron-transport chain complex I occurs with...
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