Copy Number Variation in Tumor Cells and Extracellular DNA in Patients with Lung Adenocarcinoma.
作者： D. S. Kutilin , T. G. Airapetova , P. A. Anistratov , S. P. Pyltsin , I. A. Leiman
DOI: 10.1007/S10517-019-04620-Y
关键词:
摘要: Copy number variation of some gene loci in lung tumor cells extracted by laser capture microdissection and cell-free DNA the plasma patients with cancer was analyzed for identification potential molecular markers. Tissue specimens fixed formalin embedded paraffin blocks (FFPE-blocks) from 90 extracellular samples 70 30 donors were used. assayed genes (BAX, BCL2, C-FLAR, P53, MDM2, CASP9, CASP3, CASP8, SOX2, OCT4, PIK3, MKI67, HV2, HIF1A1, XRCC1, MMP1, TERT, CTNNB1, KRAS, EGFR, GRB2, SOS1, MAPK1, STAT1, BRAF, FTO, mir3678) reference (ACTB, B2M, GAPDH) real-time quantitative PCR. Changed copy numbers detected responsible apoptosis regulation CASP3), proliferation (SOX2), reparation (XRCC1), oxidative phosphorylation (HV2), EGFR signaling pathway (GRB2, BRAF), mir3678 DNA.
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