Changes in the number of copies of genetic loci in gastric cancer
作者： О. И. Кит , Д. И. Водолажский , Д. С. Кутилин , Е. Н. Гудуева
DOI: 10.7868/S0026898415040096
关键词:
摘要: It is assumed that changes in the number of copies belong to basic mechanisms control expression genes are important for malignization. Therefore, characterization these and precise assessment understanding molecular basis tumor emergence progression human organism, as well identification predictive markers In present study, relative 19 loci (BAX, GSTP1, CASP3, CASP8, HIF1A, OCT4, C-MYC, SOX2, BCL2, CASP8/FADD, NANOG, P53, CASP9, IL-10, NFKB1, HV2, ACTB) cancerous conventionally healthy tissues from 25 residents southern Russia with a histologically confirmed diagnosis adenocarcinoma (stages G1-G2 G3) or signet cell gastric cancer were determined by quantitative real-time PCR. Changes gene shown be specific particular histological types cancer, depend on stage differentiation. The data suggest BAX, ACTB, MKI67, P53 play an role malignization tissue.
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