Lactobacillus pentosus var. plantarum C29 protects scopolamine‐induced memory deficit in mice

摘要: Aims In the preliminary study, kimchi, a traditional food fermented with Chinese cabbage, protected scopolamine-induced mouse memory deficit in passive avoidance test. Therefore, we screened protective ingredients, particularly lactic acid bacteria, from cabbage kimchi against mice. Methods and Results Lactic isolated were identified by 16S rDNA sequence analysis, G+C content cellular fatty composition sugar fermentation Memory was induced mice intraperitoneally injecting scopolamine. Kimchi, its supernatant, Of bacterium, strain C29, potently mice. C29 gram-positive, catalase-negative, anaerobic non-motile rod. Its pylogenetic property near to Lactobacillus pentosus (99%) Lact. plantarum (99%). However, inulin L-rhamnose grew pH 3 at 45°C contrast Lact. pentosus Lact. plantarum. it named be Lact pentosus var. plantarum C29. The Y-maze Morris water maze tests. Furthermore, increased hippocampal BDNF p-CREB expressions, which reduced scopolamine. Conclusion Lactobacillus may protect inducing expressions. Significance Impact of Study Lactic such as prevent contained foods beneficial for dementia.