The McLean-Harvard first-episode mania study: Prediction of recovery and first recurrence
作者： Mauricio Tohen , Carlos A. Zarate , John Hennen , Hari-Mandir Kaur Khalsa , Stephen M. Strakowski
DOI: 10.1176/APPI.AJP.160.12.2099
关键词:
摘要: OBJECTIVE: Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new onset following hospitalization for mania. METHOD: Bipolar patients (N=166) were followed 2–4 years after their a manic or mixed episode assess timing predictors outcomes. Three aspects recovery measured: syndromal (DSM-IV criteria no longer met), symptomatic (Young Mania Rating Scale score ≤5 Hamilton Depression ≤8), functional (regaining premorbid occupational residential status). Rates remission (syndromal sustained ≥8 weeks), switching (onset dissimilar before recovery), relapse (new mania within 8 weeks recurrence postremission) also assessed. RESULTS: By 2 years, most subjects achieved (98%, with 50% achieving...
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