Nutrition Influences Caffeine-Mediated Sleep Loss in Drosophila.

摘要: Study objectives Plant-derived caffeine is regarded as a defensive compound produced to prevent herbivory. Caffeine generally repellent insects and often used study the neurological basis for aversive responses in model insect, Drosophila melanogaster. also studied its stimulatory properties where sleep or drowsiness suppressed across range of species. Since limiting access food inhibits fly sleep-an effect known starvation-induced suppression-we tested whether aversion caffeinated results reduced nutrient intake assessed how this might influence studies on effects caffeine. Methods We measured total consumption during first 24 hours exposure diets containing sucrose concentrations determine relative ingestion sleep. Experiments were replicated using three strains. Results nighttime sleep, but only at intermediate concentrations. Although can be modeled by an exponential dose response intake, caffeine-mediated loss cannot explained absolute alone. Instead, strongly correlates with changes due Other bitter compounds phenocopy intake. Conclusions Our suggest that major dietary feeding behavior. Changes behavior may drive loss. Future psychoactive should consider potential impact nutrition when investigating