The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia
作者： G Klein , E Vellenga , M.W Fraaije , W.A Kamps , E.S.J.M. de Bont
DOI: 10.1016/J.CRITREVONC.2003.09.001
关键词:
摘要: In the past decades, a lot of effort has been put in identifying role matrix metalloproteinases (MMPs) cancer. The main MMPs angiogenesis, tumor growth and metastasis is degradation extracellular (ECM) release and/or activation factors through their degradative activity. activity finally results cancer progression. MMP-inhibitors (MMPIs) have already designed tested, based on First clinical trials with MMPIs performed disappointing results, showing that order to use MMP-inhibition mechanisms underlying MMP-expression be further elucidated. This paper reviews molecular cellular level discusses for special focus acute leukemia.
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