Prognosis of lymph node-negative breast cancer: Association with clinicopathological factors and tumor associated gene expression.

摘要: The aim of the present study was to investigate association between prognosis lymph node-negative breast cancer patients and clinicopathological factors, as well tumor-associated gene expression prognosis. Clinical data survival information collected for 341 with cancer, admitted Cancer Hospital Chinese Academy Medical Sciences (Beijing, China) from 1995 1999. Kaplan-Meier analysis Log-rank tests were used evaluate clinical parameters In addition, HER2, TOP2A CCND1 in good [disease-free (DFS), ≥5 years] poor (DFS, 35 years old higher compared those under age 35. Tumor size significantly affected 5-year DFS. Patients smaller tumors (≤2 cm) had a DFS rate larger (>2 cm). Estrogen receptor (ER)-positive OS ER-negative patients. By contrast, there no significant differences rates progesterone receptor-positive -negative treated adjuvant hormone therapy, without therapy. HER2 protein prognosis; however, results quantitative polymerase chain reaction showed that not different at diagnosis, tumor size, ER status therapy associated cancer. molecular biomarker, but or TOP2A, may be critical factor predicting