Cyclin D1 in invasive breast carcinoma: favourable prognostic significance in unselected patients and within subgroups with an aggressive phenotype

摘要: Aims: To study the clinicopathological and prognostic value of cyclin D1 overexpression in patients with breast carcinoma. Methods results: Immunohistochemistry was performed on paraffin-embedded tissue specimens from 290 invasive carcinomas to detect proteins D1, oestrogen receptor (ER), progesterone (PR), p53, c-erbB2, topoisomerase IIa (topoIIa). Cyclin staining quantified using a computerized image analysis method. characterized smaller, ER-positive PR-positive tumours (P = 0.017, P < 0.0001, respectively), lower histological nuclear grade 0.011 reduced expression topoIIa 0.001) p53 0.001). found have an independent favourable impact overall survival both unselected cohort 0.011) ER-negative lymph node-positive 0.034 0.015, respectively). In triple-negative tumours, impacts relapse-free 0.002 for both). Conclusions: This is first immunohistochemical dissociate advantageous effect its association ER expression, provide evidence that may be marker prolonged patient subgroups aggressive phenotypes.