Prognostic significance of the co-expression of p53 and c-erbB-2 proteins in breast cancer.

摘要: The immunohistochemical expression of p53 and c-erbB-2 gene proteins was examined in a series 130 breast adenocarcinomas. This study intended to investigate whether the frequency altered tumour suppressor overexpression oncogene cancer tissue cells correlated with other variables known affect biological behaviour these tumours overall survival patients (median follow-up time : 6 years). protein product evaluated immunohistochemically. Expression detected 30 (23 per cent) neoplasms examined, while 26 (20 out cases demonstrated positive immunoreactivity. There statistically significant association between primary size, lymph node involvement, oestrogen receptor positivity. incidence positivity significantly high grade, axillary invasion, large absence steroid receptors. immuno-expression clearly associated overexpression. Concomitant immunolabelling, which emerged 14 (10.7 cent), nodal status, ductal infiltrating (NOS) histological type, low values progesterone Overall not related immunoreactivity either or considered separately, whereas there trend worse prognosis cancers double p53/c-erbB-2 phenotype. simultaneous immunodetection appears have greater negative prognostic relevance than their separate expression.