Recent advances in melanoma research via “omics” platforms

摘要: Melanoma has a high mortality rate and metastatic melanoma is highly resistant to conventional therapies. "Omics" fields such as proteomics microRNA exosome studies have provided new knowledge complement the information generated by genomic studies. This work aimed review current status of biomarker discovery for through multi-"omics" platforms. A few sets novel microRNAs proteins are described, some them with important implications in suppressing at different stages. Upregulation genes involved angiogenesis, immunosuppressive factors, modification stroma, capture cells lymph nodes factors responsible tumour cell recruitment been identified exosomes, among molecules other functions. remarkable series epithelial-mesenchymal/mesenchymal-epithelial transitions, inflammation, motility, proliferation progression processes, centrosome amplification, aneuploidy, inhibition CD8+ effector T-cells, metastasis general were identified. Genomic protein-protein interactions or metabolome levels not analysed. Proteomics tools Orbitrap shotgun mass spectrometry deep mining proteomic analysis utilizing high-resolution reversed phase nanoseparation combination also discussed. The application these together bioinformatics approaches applied clinical setting will enable implementation personalized medicine near future.