New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid
作者： Boris Yagen , Dan Kaufmann , Eyal Sobol , Meir Bialer
DOI:
关键词:
摘要: The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses for treating psychotic disorders, neurodegenerative diseases, epilepsy pain.
lens.org 参考文章(31)
Volker Schurig, Boris Yagen, Ofer Spiegelstein, Michael Roeder, Meir Bialer, Amelioration of neurological disorders by the administration of (2R),(3S), and/or (2S),3(S) stereoisomers of valnoctamide ,(1998)
Meir Bialer, Salim Hadad, Bashier Kadry, Ali Abdul‐Hai, Abdulla Haj‐Yehia, Jeff Sterling, Yaacov Herzig, Boris Yagen, Pharmacokinetic analysis and antiepileptic activity of tetra-methylcyclopropane analogues of valpromide. Pharmaceutical Research. ,vol. 13, pp. 284- 289 ,(1996) , 10.1023/A:1016055517724
Mitchell Shirvan, Jeff Sterling, David Lerner, Jacob Herzig, Meir Bialer, Salim Hadad, Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents ,(1993)
Mitchell Shirvan, Meir Bialer, Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders ,(2001)
Meir Bialer, Mitchell Shirvan, Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder ,(2001)
Boris Yagen, Meir Blaler, Niv Papo, Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation ,(2000)
Boris Yagen, Ofer Spigelstein, Meir Bialer, Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them ,(1999)
Alexander Huber, Martin Güttinger, Hanns Möhler, Detlev Boison, Seizure suppression by adenosine A2A receptor activation in a rat model of audiogenic brainstem epilepsy Neuroscience Letters. ,vol. 329, pp. 289- 292 ,(2002) , 10.1016/S0304-3940(02)00684-5
Kwangsup Sheen, Jin Mo Chung, Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model. Brain Research. ,vol. 610, pp. 62- 68 ,(1993) , 10.1016/0006-8993(93)91217-G
S. SHUTO, H. TAKADA, D. MOCHIZUKI, R. TSUJITA, Y. HASE, S. ONO, N. SHIBUYA, A. MATSUDA, (.+-.)-(Z)-2-(Aminomethyl)-1-phenylcyclopropanecarboxamide Derivatives as a New Prototype of NMDA Receptor Antagonists. ChemInform. ,vol. 26, ,(1995) , 10.1002/CHIN.199547106