Anti-clusterin monotherapy for cancer treatment
作者： Shoshi Tessler , Tania Fine , Joel Kaye , Rina Kashi
DOI:
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摘要: The present invention provides a method of treating cancer in subject afflicted with comprising administering to the an anti-clusterin oligonucleotide as monotherapy treat cancer. also compositions for cancer, having sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1). Additionally, pharmaceutical composition 1), wherein has phosphorothioate backbone throughout, sugar moieties nucleotides 1-4 and 18-21 bearing 2′-O-methoxyethyl modifications, 5-17 which are 2′deoxynucleotides, 5-methylcytosines at 1, 4, 19.
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