Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.
作者： K. C. Nicolaou , Pradip K. Sasmal , A. J. Roecker , Xiao-Wen Sun , Sunil Mandal
关键词:
摘要:
sci-hub.se 参考文章(35)
John N. Bilton, Howard B. Broughton, Philip S. Jones, Steven V. Ley, Henry S. Rzepa, Richard N. Sheppard, Alexandra M.Z. Slawin, David J. Williams, Zev Lidert, E. David Morgan, An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives Tetrahedron. ,vol. 43, pp. 2805- 2815 ,(1987) , 10.1016/S0040-4020(01)86886-1
Neem: today and in the new millennium. Neem: today and in the new millennium.. ,(2004) , 10.1007/1-4020-2596-3
K. C. Nicolaou, Markus Follmann, A. J. Roecker, Kevin W. Hunt, Model Studies Towards Azadirachtin: Part 1. Construction of the Crowded C8bC14 Bond by Radical Chemistry We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, postdoctoral fellowships from Bayer AG (to M.F.) and the G. E. Hewitt Foundation (to K.W.H.), a predoctoral fellowship from the Division of Organic Chemistry of the American Chemical Society sponsored by Novartis (to A.J.R.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie International Edition. ,vol. 41, pp. 2103- 2106 ,(2002) , 10.1002/1521-3773(20020617)41:12<2103::AID-ANIE2103>3.0.CO;2-S
J. M. Kanabus-Kaminska, J. A. Hawari, D. Griller, C. Chatgilialoglu, Reduction of silicon-hydrogen bond strengths Journal of the American Chemical Society. ,vol. 109, pp. 5267- 5268 ,(1987) , 10.1021/JA00251A035
Stix G, Village pharmacy. The neem tree yields products from pesticides to soap. Scientific American. ,vol. 266, pp. 132- ,(1992)
A. Srikrishna, G. Sundarababu, A radical cyclisation reaction based strategy to 2,3,5-tri- and tetrasubstituted furans Tetrahedron. ,vol. 46, pp. 7901- 7910 ,(1990) , 10.1016/S0040-4020(01)90088-2
S. V. Ley, A. A. Denholm, A. Wood, The chemistry of azadirachtin Natural Product Reports. ,vol. 10, pp. 109- 157 ,(1993) , 10.1039/NP9931000109
Yuji Nishikimi, Takamasa Iimori, Mikiko Sodeoka, Masakatsu Shibasaki, Synthetic studies of azadirachtin. Synthesis of the cyclic acetal intermediate in the naturally occurring form Journal of Organic Chemistry. ,vol. 54, pp. 3354- 3359 ,(1989) , 10.1021/JO00275A020
W. Kraus, M. Bokel, A. Bruhn, R. Cramer, I. Klaiber, A. Klenk, G. Nagl, H. Pöhnl, H. Sadlo, B. Vogler, Structure determination by nmr of azadirachtin and related compounds from azadirachta indica a. Juss (Meliaceae) Tetrahedron. ,vol. 43, pp. 2817- 2830 ,(1987) , 10.1016/S0040-4020(01)86887-3
Takehiro Fukuzaki, Satoshi Kobayashi, Takamasa Hibi, Yohei Ikuma, Jun Ishihara, Naoki Kanoh, Akio Murai, Studies aimed at the total synthesis of azadirachtin. A modeled connection of C-8 and C-14 in azadirachtin. Organic Letters. ,vol. 4, pp. 2877- 2880 ,(2002) , 10.1021/OL026260Y