CD48 is a key molecule of immunomodulation affecting prognosis in glioma
作者： Cunyi Zou , Chen Zhu , Gefei Guan , Qing Guo , Tianqi Liu
DOI: 10.2147/OTT.S198762
关键词:
摘要: Purpose: Glioma is a refractory disease associated with immune cell infiltration, and the effectiveness of checkpoint blockade remains suboptimal. As an adhesion costimulatory molecule, CD48 plays significant role in immunomodulation. such, studying may provide additional understanding inflammation response glioma. Methods: Using R language GraphPad Prism 7, RNA sequencing data 946 patients from Chinese Genome Atlas and The Cancer Atlas cohorts were analyzed. Results: was highly expressed malignant progression glioma. independent risk factor, high-CD48 poor prognosis. influenced glioma purity local subpopulation. closely related to function Patients enhanced phenotype, high CD48, suppressive molecules checkpoints. In addition, correlated inflammatory response. A score including SLAMF8 PD-L1 used assess Risk particularly subtype predictive indicator unfavorable outcome. Additionally, age, IDH MGMT promoter status significance score. Conclusion: exhibits crucial reduced survival immunomodulation we found that checkpoints play greater older than 40 years old wild-type methylated status. These findings suggest combining be promising approach immunotherapy for specific subpopulations patients.
sci-hub.se 参考文章(49)
Erika Assarsson, Taku Kambayashi, John D. Schatzle, Sven O. Cramer, Arne von Bonin, Peter E. Jensen, Hans-Gustaf Ljunggren, Benedict J. Chambers, NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions Journal of Immunology. ,vol. 173, pp. 174- 180 ,(2004) , 10.4049/JIMMUNOL.173.1.174
Zhong Zheng Jia, Hong Mei Gu, Xue Jun Zhou, Jin Long Shi, Min Da Li, Guo Feng Zhou, Xian Hua Wu, The assessment of immature microvascular density in brain gliomas with dynamic contrast-enhanced magnetic resonance imaging. European Journal of Radiology. ,vol. 84, pp. 1805- 1809 ,(2015) , 10.1016/J.EJRAD.2015.05.035
Katalin Kis-Toth, George C. Tsokos, Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival Journal of Immunology. ,vol. 192, pp. 4436- 4442 ,(2014) , 10.4049/JIMMUNOL.1302909
David H Canaday, Karen E Parker, Htin Aung, Hui Emily Chen, Dariana Nunez-Medina, Christopher J Burant, Age-dependent changes in the expression of regulatory cell surface ligands in activated human T-cells BMC Immunology. ,vol. 14, pp. 45- 45 ,(2013) , 10.1186/1471-2172-14-45
Ela Martin, Brendan O'Sullivan, Pauline Low, Ranjeny Thomas, Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity. ,vol. 18, pp. 155- 167 ,(2003) , 10.1016/S1074-7613(02)00503-4
Jeremy N. Rich, Darell D. Bigner, Development of novel targeted therapies in the treatment of malignant glioma Nature Reviews Drug Discovery. ,vol. 3, pp. 430- 446 ,(2004) , 10.1038/NRD1380
Nathan R West, Katy Milne, Pauline T Truong, Nicol Macpherson, Brad H Nelson, Peter H Watson, Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer Breast Cancer Research. ,vol. 13, pp. 1- 13 ,(2011) , 10.1186/BCR3072
Yan Wu, Dong-Ming Kuang, Wei-Dong Pan, Yun-Le Wan, Xiang-Ming Lao, Dian Wang, Xue-Feng Li, Limin Zheng, Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions† Hepatology. ,vol. 57, pp. 1107- 1116 ,(2013) , 10.1002/HEP.26192
Achim Rody, Uwe Holtrich, Laos Pusztai, Cornelia Liedtke, Regine Gaetje, Eugen Ruckhaeberle, Christine Solbach, Lars Hanker, Andre Ahr, Dirk Metzler, Knut Engels, Thomas Karn, Manfred Kaufmann, None, T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers Breast Cancer Research. ,vol. 11, pp. 1- 13 ,(2009) , 10.1186/BCR2234
S Han, J Xia, X Qin, S Han, A Wu, Phosphorylated SATB1 is associated with the progression and prognosis of glioma Cell Death and Disease. ,vol. 4, ,(2013) , 10.1038/CDDIS.2013.433