Photoaquation of cis-dichlorobis-(1,10-phenanthroline)chromium(III) and the photochemical and thermal reactions of this complex with native calf-thymus DNA.
作者： Mark A. Billadeau , Harry Morrison
DOI: 10.1016/0162-0134(94)00029-A
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摘要: The photoaquation of the title compound [cis-Cr(phen)2CL+2] has been studied using high performance liquid chromatography. Both monoaquo [cis-Cr(phen)2Cl(OH2)2+2] and diaquo [cis-Cr(phen)2(OH2)3+2] products are formed, quantum efficiency for loss starting material in Tris buffer (pH 7) under argon oxygen is 0.010 ± 0.001 0.0026 0.0002, respectively. presence deoxyguanosine (dG) increases rate loss, as much twofold argon, but only product formation enhanced by nucleoside. dG effect attributed to reductive quenching cis-Cr(phen)2Cl+2 excited state base. Equilibrium dialysis studies indicate that both cisCr(phen)2(OH2)3+2 minimally associate with calf-thymus DNA. However, photolyses nucleic acid yield a mixture unidentified covalent adducts. complex also forms adducts DNA absence light. Photolyses polyribonucleotides clear preference binding purines.
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